Which of the following is true of long-term depression (LTD)?
A) LTD can be produced by high-frequency stimulation of CA1 neurons.
B) LTD reflects a gradual strengthening of synaptic connections.
C) LTD is associated with a decrease in the number of AMPA receptors in the postsynaptic neuron.
D) LTD is associated with an increase in the number of AMPA receptors in the postsynaptic neurons.
E) LTD is not an associative phenomenon.

Question

Quizplus · Accepted Answer

LTD is associated with a decrease in the number of AMPA receptors in the postsynaptic neuron. This is due to the internalization of AMPA receptors from the postsynaptic membrane, which reduces the efficacy of synaptic transmission.

Note: A is also partially true, as LTD can be induced by low-frequency stimulation. However, high-frequency stimulation can induce long-term potentiation (LTP) instead. B, D, and E are false statements.

Which of the Following Is True of Long-Term Depression (LTD)