Persistence of long-term potentiation for more than an hour requires
A) formation of new axonal spines.
B) presynaptic inhibition of glutamate release.
C) increased protein synthesis within the postsynaptic dendrite.
D) insertion of GABA receptors into the postsynaptic membrane.
E) destruction of AMPA receptors in the postsynaptic membrane.

Question

Quizplus · Accepted Answer

Long-term potentiation (LTP) is a long-lasting increase in the strength of synaptic transmission. LTP lasting for more than an hour requires increased protein synthesis within the postsynaptic dendrite. This protein synthesis leads to the incorporation of new AMPA receptors into the postsynaptic membrane, which is thought to be the primary mechanism responsible for the persistence of LTP. Formation of new axonal spines (A), presynaptic inhibition of glutamate release (B), insertion of GABA receptors into the postsynaptic membrane (D), and destruction of AMPA receptors in the postsynaptic membrane (E) may play a role in synaptic plasticity but are not necessary for the persistence of LTP for more than an hour.

Persistence of Long-Term Potentiation for More Than an Hour Requires