What Is the Relationship Between the HIV-1 Virus and Brain

What is the relationship between the HIV-1 virus and brain damage?

A) The virus itself never causes brain damage, only peripheral damage to the skin.
B) The virus may work indirectly: It allows infections to occur that cause brain damage.
C) The virus does not lead to brain damage, but the disease so affects patients that their psychotic reactions mimic those of brain damage.
D) The virus is more likely to multiple in a brain that has already been damaged by brain trauma or some other cause of tissue loss.