The "first pass" metabolism effect will occur primarily with drugs administered
A)orally
B)rectally
C)subcutaneously
D)intravenously

Question

Quizplus · Accepted Answer

First pass metabolism refers to the initial metabolism or breakdown of drugs in the liver before they enter the systemic circulation. This effect is most pronounced when drugs are administered orally since they will be absorbed through the gastrointestinal tract and transported directly to the liver via the hepatic portal vein. This effect is less pronounced with other routes of administration such as rectal, subcutaneous or intravenous, where the drugs bypass the liver and enter the circulation directly.

The "First Pass" Metabolism Effect Will Occur Primarily with Drugs