Physical dependence associated with down-regulation of receptors is most likely to occur with drugs that
A)deplete neurotransmitters
B)reduce receptor activation
C)increase receptor activation
D)enhance hepatic enzyme production

Question

Quizplus · Accepted Answer

Physical dependence is associated with down-regulation of receptors, meaning that the receptors become less responsive to the drug over time. This is most likely to occur with drugs that increase receptor activation by binding to and activating the receptors repeatedly, leading to a decrease in the number of available receptors and a decrease in their sensitivity to the drug. Choices A and B are less likely to lead to down-regulation of receptors, while choice D is unrelated to receptor regulation.

Physical Dependence Associated with Down-Regulation of Receptors Is Most Likely