Distinguish between "context-specific" tolerance and "pharmacodynamic" tolerance.

Question

Quizplus · Accepted Answer

The Answer is Context-specific tolerance refers to a decrease in response to a drug primarily resulting from learning processes, in which the contextual stimuli become CSs for compensatory CRs that reduce the apparent drug-induced reactions (UCRs), or the organism learns instrumental compensatory responses to behaviorally disruptive effects of the drug, or simple habituation occurs to the drug stimuli.If the contextual stimuli are changed or the task contingencies change, the tolerance may be reduced or eliminated.Pharmacodynamic tolerance refers to changes in cellular membranes, receptors, or neurotransmitter levels reflecting physiological homeostatic processes.These processes are activated when the concentration of the drug is high and the actions are prolonged and are generally independent of the context in which the drug is taken.

Distinguish Between "Context-Specific" Tolerance and "Pharmacodynamic" Tolerance