The earliest catecholamine hypothesis of affective disorders suggested that depression results from

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The earliest catecholamine hypothesis of affective disorders suggested that depression results from a deficiency of norepinephrine and/or dopamine in the brain. This hypothesis was based on evidence that antidepressant medications increase the availability of these neurotransmitters in synapses. However, this hypothesis has since been revised and updated to incorporate a more complex understanding of the underlying neurobiology of depression.

The Earliest Catecholamine Hypothesis of Affective Disorders Suggested That Depression