What is the main source of the energy required to form phosphodiester linkages during the addition of nucleotides to growing DNA strands?
A) Hydrolysis of ATPs
B) Hydrolysis of dNTPs
C) Hydrolysis of NADP
D) Enzymes
E) The reaction does not require the input of energy.

Question

Quizplus · Accepted Answer

The energy required to form phosphodiester linkages during DNA synthesis comes from the hydrolysis of dNTPs (deoxynucleoside triphosphates) that are paired up to complementary nucleotides during base pairing. The release of two phosphate groups from the dNTP molecule provides the energy needed for the formation of a phosphodiester bond between the 5' phosphate of the incoming nucleotide and the 3' hydroxyl group of the previous nucleotide in the growing strand. ATP hydrolysis is also involved in DNA synthesis, but it serves as an energy source for the enzymes that drive DNA polymerization and other steps in the replication process. NADP is not involved in DNA synthesis, and the reaction requires the input of energy, which is supplied by the hydrolysis of dNTPs.

What Is the Main Source of the Energy Required to Form