Which transfusion is most likely to cause an immune reaction?
A) A transfusion of O type blood to a person with A type blood
B) A transfusion of A type blood to a person with O type blood
C) A transfusion of B type blood to a person with AB type blood
D) A transfusion of O type blood to a person with O type blood
E) A transfusion of AB type blood to a person with AB type blood

Question

Quizplus · Accepted Answer

A person with O type blood has both anti-A and anti-B antibodies in their blood, so if they receive a transfusion of A type blood (which contains A antigens), their antibodies will recognize the antigens as foreign and mount an immune response, potentially leading to a transfusion reaction. The other options either involve a person receiving their own blood type (D) or receiving a blood type that their body is already compatible with (A, C, E).

Which Transfusion Is Most Likely to Cause an Immune Reaction