Very high cholesterol levels in those with familial hypercholesterolemia are cause by
A) hyperactive aquaporins.
B) the inability to hydrolyze ATP.
C) deficient LDL receptor proteins.
D) malformed gap junctions.
E) defective ion channels.

Question

Quizplus · Accepted Answer

Familial hypercholesterolemia is caused by deficient LDL receptor proteins, which results in high levels of LDL (low-density lipoprotein) cholesterol in the blood. This is because LDL receptors are responsible for removing LDL cholesterol from the blood by taking it up into cells. When there are not enough functional LDL receptors, LDL cholesterol accumulates in the blood, leading to increased risk for cardiovascular disease.

Very High Cholesterol Levels in Those with Familial Hypercholesterolemia Are