One disadvantage of a multiple-treatment design compared to a two-treatment design is that the likelihood of participant attrition increases as the number of treatments increases.

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Participants may experience fatigue or become disengaged with the study as the number of treatments increases, which can increase the likelihood of participant attrition. This can be a disadvantage of multiple-treatment designs compared to two-treatment designs, where participants are only exposed to two conditions.

One Disadvantage of a Multiple-Treatment Design Compared to a Two-Treatment