Achondroplastic dwarfism is a hereditary condition,in which the long bones of the limbs fail to elongate normally because of reduced hyperplasia and hypertrophy of cartilage in the __________.
A) primary ossification center
B) secondary ossification center
C) primary bone marrow
D) secondary bone marrow
E) epiphyseal plate

Question

Quizplus · Accepted Answer

Achondroplastic dwarfism is caused by a mutation in the fibroblast growth factor receptor (FGFR3) gene, which impairs the proliferation and differentiation of chondrocytes in the epiphyseal plate, leading to the shortened limbs characteristic of the condition. Therefore, the correct answer is E) epiphyseal plate.

Achondroplastic Dwarfism Is a Hereditary Condition,in Which the Long Bones