Which of the following best describes the wobble hypothesis?
(I)The degree of variance in base pairing is greater at the 5' end of the anticodon,thus accounting for more than one codon.
(II)The degree of variance in base pairing is greater at the 3' end of the anticodon,thus accounting for more than one codon
(III)Non-Watson-Crick base pairing is sometimes allowed in the last position of the anticodon-codon pairing.
A)I only
B)II only
C)I and III
D)II and III
E)III only

Question

Quizplus · Accepted Answer

The wobble hypothesis refers to the ability of certain tRNA molecules to recognize more than one codon due to non-Watson-Crick base pairing at the third position of the codon and the first position of the anticodon. This is described by statement III. Additionally, the degree of variance in base pairing is greater at the 5' end of the anticodon, which is also mentioned in statement I. Therefore, the best choice is C. Statement II is incorrect as the degree of variance is actually greater at the 5' end, not the 3' end.

Which of the Following Best Describes the Wobble Hypothesis