Which of the following increases the affinity of SH2 binding to phosphor-tyrosine?
A)The absence of a Ser or Thr residue in the binding region.
B)The presence of an Arg residue deep in the binding pocket.
C)The presence of an Arg residue near the binding pocket entrance.
D)The absence of a Ser residue deep in the binding pocket.
E)None of the above.

Question

Quizplus · Accepted Answer

The presence of an Arg residue deep in the binding pocket increases the affinity of SH2 domains for phosphor-tyrosine by stabilizing the binding through electrostatic interactions with the negatively charged phosphate group.

Which of the Following Increases the Affinity of SH2 Binding