Which of the following is TRUE regarding transition state?
A)The free energy between the transition state and the reactants must be negative.
B)The transition state can be stabilized by covalent catalysis.
C)The transition state represents the ES complex.
D)Transition state analogs bind the substrate not the enzyme
E)All of the above are true.

Question

Quizplus · Accepted Answer

The transition state can be stabilized by covalent catalysis through the formation of a covalent bond between the enzyme and the transition state, lowering the energy required for the reaction to occur. The free energy between the transition state and the reactants must be positive, not negative, as the transition state represents the highest energy point in the reaction pathway. The transition state is not the ES complex, which represents the enzyme-substrate complex before the reaction occurs. Transition state analogs bind to the enzyme, mimicking the transition state but not the substrate.

Which of the Following Is TRUE Regarding Transition State