Both hyposecretion and hypersecretion of thyroxine can lead to goiter.

Name: Both hyposecretion and hypersecretion of thyroxine can lead to goiter.
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Hyposecretion of thyroxine (as seen in hypothyroidism) can lead to goiter due to the thyroid gland enlarging in an attempt to produce more hormone. Similarly, hypersecretion of thyroxine (as seen in hyperthyroidism) can also lead to goiter due to overstimulation of the thyroid gland.

Both Hyposecretion and Hypersecretion of Thyroxine Can Lead to Goiter