Following cerebral ischemia,
A) glutamate is released in excessive quantities.
B) excessive activity is induced at NMDA receptors.
C) excessive numbers of calcium and sodium ions enter postsynaptic neurons.
D) postsynaptic neurons slowly die.
E) all of the above

Question

Quizplus · Accepted Answer

Following cerebral ischemia, all of the above events occur. Glutamate is released in excessive quantities, leading to overactivation of NMDA receptors and subsequent entry of excessive calcium and sodium ions into postsynaptic neurons. This can cause neuronal damage and cell death.

Following Cerebral Ischemia