When Considering the Rate of Nucleotide Divergence for a Particular

When considering the rate of nucleotide divergence for a particular gene over time,which of the following has been observed to be true?

A) Nonsynonymous mutations will become established less frequently.
B) Adenine nucleotides are more readily mutated than other nucleotides.
C) Synonymous mutations will become established less frequently.
D) Nucleotide changes over time are impossible to measure.
E) Only noncoding sequences display change.