How does a nonsense suppressor mutation prevent amber mutants from terminating their polypeptides prematurely?
A)The mutation turns the amber codon back into a wild-type codon.
B)The mutation alters a tRNA so that it reads the amber codon and inserts an amino acid.
C)The mutation alters the release factors that would halt synthesis.
D)The mutation results in a wobble that allows synthesis to continue.
E)The mutation replaces the amber codon with an ochre codon.

Question

Quizplus · Accepted Answer

A nonsense suppressor mutation alters a tRNA so that it can recognize and insert an amino acid at a premature stop codon, in this case the amber codon. This allows the polypeptide synthesis to continue beyond the point where it would normally be terminated.

How Does a Nonsense Suppressor Mutation Prevent Amber Mutants from Terminating