Cell-cycle progress enables the initiation of genome replication by:
A)activating DNA polymerase III activity directly.
B)providing Cdc6 and Cdt1,which aid assembly of initiation components at the origin of replication.
C)activating histone degradation near the origin of replication.
D)activating expression of the ORC protein and helicase proteins.
E)All of the answer options are correct.

Question

Quizplus · Accepted Answer

Cell-cycle progress enables the initiation of genome replication by providing Cdc6 and Cdt1, which aid assembly of initiation components at the origin of replication. These proteins help to load the MCM helicase onto DNA at the origin, which is the initial step in replication initiation. Other factors, such as the ORC protein and helicase proteins, may also be involved in this process but are not directly activated by cell-cycle progress. Histone degradation also plays a role in replication initiation, but it occurs after MCM loading and is not directly activated by cell-cycle progress. Therefore, the best choice is B.

Cell-Cycle Progress Enables the Initiation of Genome Replication By