Deletion or insertion mutations cause
A) base-pair substitutions.
B) frameshifts.
C) sickle cell anemia.
D) gene duplications.
E) no change in the gene affected.

Question

Quizplus · Accepted Answer

Deletion or insertion mutations cause frameshifts, which shift the reading frame of the codons in the gene sequence, altering the amino acid sequence of the protein product. This can have significant effects on the function of the protein and potentially lead to disease. Base-pair substitutions, on the other hand, involve the replacement of a single nucleotide with another and may or may not lead to a change in the amino acid sequence. Sickle cell anemia is caused by a specific base-pair substitution, while gene duplications occur when a region of the genome is duplicated, resulting in an increase in the number of copies of a gene.

Deletion or Insertion Mutations Cause