Which of the following mutations always lead(s)to a shift of the mRNA's reading frame?
A) deletion and insertion
B) deletion and substitution
C) insertion and substitution
D) substitution
E) insertion

Question

Quizplus · Accepted Answer

Deletions and insertions change the number of nucleotides in the mRNA sequence, which causes a shift in the reading frame. This means that the mRNA is read in a different set of three-nucleotide codons, resulting in a completely different amino acid sequence for the protein that is ultimately produced. Substitutions, on the other hand, only affect a single nucleotide and may or may not cause a shift in the reading frame depending on their location in the codon.

Which of the Following Mutations Always Lead(s)to a Shift of the MRNA's