The development of self-tolerance through B cell and T cell inactivation after antigen recognition without the second costimulation signal involves which process?
A)apoptosis
B)anergy
C)deletion
D)reactivity
E)selectivity

Question

Quizplus · Accepted Answer

The process described is known as anergy, which involves inactivation of B cell or T cell without receiving the second costimulation signal. This leads to the development of self-tolerance and prevents activation of immune cells against self-antigens. Anergy is usually achieved through the induction of a state of unresponsiveness in the cells rather than inducing apoptosis or deletion of the self-reactive cells. Therefore, choices A and C are not the best options. Choices D and E do not describe the process of B cell and T cell inactivation without the second costimulation signal, so they are not the best choices.

The Development of Self-Tolerance Through B Cell and T Cell