Based on the following, what can be said about the synthesis of polynucleotides?
A)polynucleotides are unstable and are rapidly degraded
B)polynucleotide formation is made much more exergonic by the hydrolysis of pyrophosphate
C)the hydrolysis of nucleoside triphosphates is the only driving force to make an overall irreversible reaction
D)polynucleotides are highly resistant to hydrolysis, even in the presence of an acid catalyst
E)none of the above

Question

Based on the following, what can be said about the synthesis of polynucleotides? 
A)polynucleotides are unstable and are rapidly degraded 
B)polynucleotide formation is made much more exergonic by the hydrolysis of pyrophosphate 
C)the hydrolysis of nucleoside triphosphates is the only driving force to make an overall irreversible reaction 
D)polynucleotides are highly resistant to hydrolysis, even in the presence of an acid catalyst 
E)none of the above

Quizplus · Accepted Answer

The hydrolysis of pyrophosphate makes the formation of polynucleotides much more exergonic and drives the overall irreversible reaction forward.

Based on the Following, What Can Be Said About the Synthesis