A disadvantage of using an attenuated live microbe in a vaccine is that it can conceivably mutate back to a virulent strain.

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Attenuated live microbes in vaccines are weakened versions of the pathogen that are no longer able to cause disease, but they still retain some of their genetic material. In rare instances, these microbes can mutate back to a virulent strain and potentially cause disease. This is why careful monitoring and regulation is necessary for the development and distribution of attenuated live vaccines.

A Disadvantage of Using an Attenuated Live Microbe in a Vaccine