Which of these happens first in an cholinergic synaptic transmission?
A) Acetylcholine diffuses across the synaptic cleft
B) A postsynaptic potential is produced
C) Sodium enters the postsynaptic cell
D) The synaptic vesicles release acetylcholine
E) Acetylcholine binds to ligand-regulated gates

Question

Quizplus · Accepted Answer

The release of neurotransmitters from synaptic vesicles occurs before any action potential or postsynaptic potential is produced. In cholinergic synapses, the neurotransmitter released is acetylcholine.

Answer: E
 After the release of acetylcholine, it binds to ligand-regulated gates (nicotinic or muscarinic receptors) on the postsynaptic membrane. This binding opens up ion channels, allowing the influx of ions which ultimately leads to the production of a postsynaptic potential.

Which of These Happens First in an Cholinergic Synaptic Transmission