One possible reason that the proteome is so much larger than the genome is that tRNAs can be spliced in alternative ways thereby increasing the number of products produced from a particular gene.

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Quizplus · Accepted Answer

The statement is not accurate. While alternative splicing can certainly increase the diversity of proteins produced from a gene, tRNA splicing is a separate process and is not known to significantly contribute to the larger size of the proteome compared to the genome. Other factors that contribute to the larger proteome include post-translational modifications, protein degradation, and the use of alternate translation initiation sites.

One Possible Reason That the Proteome Is So Much Larger