The Guthrie test is used to screen all newborns in the United States for cystic fibrosis.

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The Guthrie test is primarily used to screen newborns for phenylketonuria (PKU) and other metabolic disorders, not specifically or exclusively for cystic fibrosis. Cystic fibrosis screening in newborns is typically done using immunoreactive trypsinogen (IRT) testing, followed by genetic testing if the IRT test is positive.

The Guthrie Test Is Used to Screen All Newborns in the United