The same neurotransmitter may produce either excitatory or inhibitory effects on postsynaptic neurons depending on the specific receptor type it binds.

Question

Quizplus · Accepted Answer

This statement is true. For example, glutamate can bind to AMPA and NMDA receptors, producing excitatory effects, or it can bind to GABA receptors, producing inhibitory effects. Similarly, GABA can bind to either GABA-A or GABA-B receptors, producing either inhibitory or mixed effects respectively. The specific receptor type determines whether the neurotransmitter will have an excitatory or inhibitory effect on the postsynaptic neuron.

The Same Neurotransmitter May Produce Either Excitatory or Inhibitory Effects