What is known to be critical for long-term potentiation?
A) high levels of magnesium
B) only one axon being active at a time
C) the absence of NMDA receptors
D) a massive inflow of calcium

Question

Quizplus · Accepted Answer

Long-term potentiation (LTP) is a process that strengthens the connection between two neurons, and it is known to be critical for learning and memory. The most important factor that triggers LTP is a massive inflow of calcium into the postsynaptic neuron, which activates a series of biochemical processes leading to the strengthening of synaptic connections. Therefore, option D is the correct answer. Option A is incorrect because magnesium blocks NMDA receptors in their resting state, which prevents calcium influx, and therefore, it is not critical for LTP. Option B is incorrect because the simultaneous activation of multiple axons can actually enhance LTP. Option C is also incorrect because NMDA receptors are essential for the induction of LTP.

What Is Known to Be Critical for Long-Term Potentiation