Endogenous cannabinoids act to:
A) decrease neurotransmitter release from presynaptic neurons.
B) block reuptake of neurotransmitter.
C) stimulate release of dopamine.
D) decrease synthesis of neurotransmitter.

Question

Quizplus · Accepted Answer

Endogenous cannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), function as retrograde messengers in the endocannabinoid system. They are synthesized by postsynaptic neurons and diffuse back to presynaptic neurons to bind to cannabinoid receptors, leading to a decrease in the release of neurotransmitter from the presynaptic neuron. This is known as retrograde inhibition and is the primary mechanism by which endocannabinoids regulate synaptic transmission.

Endogenous Cannabinoids Act To