Which change in a gene's DNA sequence would have the least effect on the eventual amino acid sequence produced from it?
A)Deletion of two consecutive nucleotides
B)Addition of one nucleotide
C)Addition/deletion of three consecutive nucleotides
D)Substitution of one nucleotide AND addition of 1 nucleotide

Question

Quizplus · Accepted Answer

Addition or deletion of three nucleotides will only cause a frameshift mutation if it is not a multiple of three. However, if it is triplet code, the codon reading frame will shift but the same amino acid sequence can be preserved. This type of mutation is called a silent mutation, which is the least disruptive type of mutation. Therefore, the addition or deletion of three consecutive nucleotides would have the least effect on the eventual amino acid sequence produced from it.

Which Change in a Gene's DNA Sequence Would Have the Least