A defect in which of the following systems leads to granulomatous disease?
A)lymphatic system
B)circulatory system
C)oxidase system
D)Golgi system

Question

Quizplus · Accepted Answer

A defect in the oxidase system, specifically the NADPH oxidase complex, leads to an inability of phagocytes to generate reactive oxygen species (ROS) necessary for killing intracellular pathogens. This leads to persistent infections and granulomatous inflammation, seen in diseases such as chronic granulomatous disease (CGD). Defects in the lymphatic and circulatory systems are not typically associated with granulomatous disease. The Golgi system is involved in protein processing and trafficking and is not directly related to granulomatous disease.

A Defect in Which of the Following Systems Leads to Granulomatous