In a typical long-term potentiation (LTP)study,a stimulating electrode is inserted into the perforant path,while a recording electrode is inserted into the dentate gyrus.LTP is produced in this preparation by delivering ________ via the stimulating electrode.
A) a long duration but low-intensity pulse
B) a single low-intensity electrical pulse
C) an electrical pulse every minute for 2-3 hours
D) a single high intensity electrical pulse
E) a burst of 100 electrical pulses in a few seconds

Question

Quizplus · Accepted Answer

LTP is typically induced by a high-frequency stimulation of afferent fibers, such as a burst of 100 electrical pulses in a few seconds. This type of stimulation has been found to cause a long-lasting increase in the strength of synaptic transmission, which is one of the hallmark features of LTP. Option A is incorrect because a low-intensity pulse is unlikely to cause LTP. Option B is incorrect because a single low-intensity pulse does not produce the type of high-frequency activity that is necessary for LTP. Option C is incorrect because an electrical pulse every minute for only 2-3 hours is not sufficient to induce LTP. Option D is incorrect because a single high-intensity pulse is not likely to induce LTP, as the intensity needs to be sustained at a high level for a certain amount of time.

In a Typical Long-Term Potentiation (LTP)study,a Stimulating Electrode Is Inserted