The peripheral chemoreceptors are not as sensitive as the central chemoreceptors.The PaO₂ must drop below 80 mm Hg before the peripheral chemoreceptors have much influence on ventilation.

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Peripheral chemoreceptors are sensitive to changes in PaO2, but they typically respond when PaO2 drops below 60 mm Hg, not 80 mm Hg. Central chemoreceptors are more sensitive to changes in CO2 and pH.

The Peripheral Chemoreceptors Are Not as Sensitive as the Central