The binding of released histamine to an H1 receptor during an allergic attack induces a pro-inflammatory state through which pathway(s)?
A) classical complement pathway
B) lipoxygenase pathway and cyclooxygenase pathway
C) signal transduction pathway, causing IL-2 production
D) lectin complement pathway
E) epinephrine-producing pathway

Question

Quizplus · Accepted Answer

The lipoxygenase pathway and cyclooxygenase pathway are two pathways that produce pro-inflammatory mediators such as leukotrienes and prostaglandins, respectively. These mediators contribute to the symptoms of an allergic reaction, such as bronchoconstriction and vasodilation. Binding of histamine to an H1 receptor can activate these pathways and induce the pro-inflammatory state. The other pathways listed (classical complement pathway, lectin complement pathway, signal transduction pathway causing IL-2 production, and epinephrine-producing pathway) do not directly contribute to the pro-inflammatory response induced by histamine binding to an H1 receptor.

The Binding of Released Histamine to an H1 Receptor During