Capping of B-cell receptors on the surface of an antigen-exposed B cell immediately causes what to occur?
A) VDJ gene switching, recombination, and hypermutation
B) neutrophil phagocytosis of the antigen
C) complement cascade signaling and antigen destruction
D) cell-signaling cascade, inducing cell proliferation and differentiation
E) helper T-cell proliferation and regulatory T-cell differentiation

Question

Quizplus · Accepted Answer

Capping of B-cell receptors on the surface of an antigen-exposed B cell immediately triggers a cell-signaling cascade. This cascade induces cell proliferation and differentiation leading to the production of plasma cells and memory B cells. VDJ gene switching, recombination, and hypermutation occur later during the germinal center reaction. Neutrophil phagocytosis of the antigen, complement cascade signaling, and helper T-cell proliferation/ regulatory T-cell differentiation are not directly triggered by B-cell receptor capping.

Capping of B-Cell Receptors on the Surface of an Antigen-Exposed