The classical pathway of complement activation involves which of the following proteins
A)C1,C4 and C2
B)C3 only
C)factor B
D)factor D and factor P

Question

Quizplus · Accepted Answer

The classical pathway of complement activation involves the initiation complex C1, which consists of subcomponents C1q, C1r, and C1s, along with downstream components C4 and C2. These proteins interact in a cascade to ultimately produce the active complement component C3b, which can then lead to opsonization, inflammation and cell lysis. This pathway is typically triggered by the binding of C1q to antigen-antibody complexes, but can also be activated by other plasma components such as C-reactive protein or certain bacterial or viral surfaces.

The Classical Pathway of Complement Activation Involves Which of the Following