Fragile X syndrome occurs most often in females because they have an extra X chromosome,giving them a greater chance of inheriting the syndrome.

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Fragile X syndrome is actually more common in males because the syndrome is caused by a mutation on the X chromosome, and males only have one X chromosome. However, females can still inherit Fragile X syndrome if they have a mutation on both their X chromosomes or if they have a mutation on one X chromosome and a non-mutated X chromosome that is inactive (due to X chromosome inactivation).

Fragile X Syndrome Occurs Most Often in Females Because They