How does progressive nephron injury affect angiotensin II activity?
A)Angiotensin II activity is decreased.
B)Angiotensin II activity is elevated.
C)Angiotensin II activity is totally suppressed.
D)Angiotensin II activity is not affected.

Question

Quizplus · Accepted Answer

Angiotensin II activity is elevated with progressive nephron injury. Angiotensin II promotes glomerular hypertension and hyperfiltration caused by efferent arteriolar vasoconstriction and also promotes systemic hypertension. The chronically high intraglomerular pressure increases glomerular capillary permeability, contributing to proteinuria. Angiotensin II also may promote the activity of inflammatory cells and growth factors that participate in tubulointerstitial fibrosis and scarring.

How Does Progressive Nephron Injury Affect Angiotensin II Activity