A genetic polymorphism that more causes lower activity of aldehyde dehyrdogenase are likely to:
A) also have inhibition of alcohol dehydrogenase enzymes.
B) have longer effects produced by alcohol.
C) experience greater effects from acetaldehyde.
D) be more affected by acetic acid.

Question

Quizplus · Accepted Answer

Aldehyde dehydrogenase is responsible for the breakdown of acetaldehyde, a toxic byproduct of alcohol metabolism. A genetic polymorphism that causes lower activity of aldehyde dehydrogenase results in higher levels of acetaldehyde in the body, leading to greater effects such as flushing, nausea, and headaches. Therefore, option C is the correct answer. Option A is incorrect as alcohol dehydrogenase is responsible for the initial breakdown of alcohol, not affected by this polymorphism. Option B is incorrect as the duration of alcohol effects is not affected by this polymorphism. Option D is incorrect as acetic acid is not directly related to alcohol metabolism.

A Genetic Polymorphism That More Causes Lower Activity of Aldehyde