T cells typically bind with HLA self-antigens only when they are in association with foreign antigen.

Question

Quizplus · Accepted Answer

T cells recognize antigens when they are presented on the surface of cells by Major Histocompatibility Complex (MHC) molecules, which in humans are also known as Human Leukocyte Antigens (HLA). The T cell receptor (TCR) binds to a complex of the HLA molecule and a foreign antigen peptide, not to HLA self-antigens alone.

T Cells Typically Bind with HLA Self-Antigens Only When They