How does pharmacodynamic tolerance develop?
A) The most acute effect of alcohol occurs after the first few drinks in a day; because the liver can only process so much alcohol, these effects become less pronounced as more drinks are consumed.
B) Over sustained periods of using alcohol, the number or sensitivity of the neuroreceptors that respond to alcohol gradually decreases.
C) Sustained use of alcohol over months or years increases the sensitivity of GABA and dopamine receptors.
D) The amount of substance that can be used in a given period of time fluctuates based on circadian cycles and, in women, menstrual cycles.

Question

Quizplus · Accepted Answer

Pharmacodynamic tolerance occurs when the neuroreceptors that respond to a substance become less sensitive or decrease in number over sustained periods of use. This means that a person needs increasingly larger doses of the substance to achieve the same effect.

How Does Pharmacodynamic Tolerance Develop