Adipocytes release leptin, which signals the brain and other tissues regarding how much fat is stored and ready to use for energy.

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Adipocytes, or fat cells, release the hormone leptin which acts on the hypothalamus in the brain to regulate food intake and energy expenditure. Leptin levels increase with an increase in fat storage, signaling the brain that there is enough energy available and reducing appetite. When fat stores decrease, leptin levels decline, stimulating hunger and increasing energy expenditure to replenish fat stores.

Adipocytes Release Leptin, Which Signals the Brain and Other Tissues