Tetrodotoxin Is a Heat-Stable Molecule Produced by Puffer Fish That

Tetrodotoxin is a heat-stable molecule produced by puffer fish that blocks the entry of sodium ions into neurons. About 10-45 minutes after ingestion of tetrodotoxin, tingling of the tongue and inner surface of the mouth begins. An ascending paralysis develops, and death can occur within 6-24 hours, after respiratory muscle paralysis.
-Why would this lead to paralysis and death?

A) Neurons run out of energy.
B) Neurons swell because of increased osmosis.
C) Neurons can't recharge.
D) Neurons can't fire without a voltage change.
E) Neurons cannot release neurotransmitters.