A newly defined interpretive category termed "Susceptible-Dose Dependent" (SDD)implies susceptibility of an isolate is dependent on dosing regimen.Which of the following statements is correct?
A)SDD is included within the susceptible category definition.
B)SDD is assigned to therapeutic agents that are approved under investigational use only.
C)The infecting organism may be effectively treated by using higher doses or more frequent doses or both of the drugs.
D)Drugs in this category have narrow therapeutic indices and their use at nonconventional ways must be monitored closely.

Question

Quizplus · Accepted Answer

"Susceptible-Dose Dependent" (SDD)is included within the susceptible category definition.SDD implies susceptibility of an isolate is dependent on dosing regimen and by altering dosing (higher or more frequent doses or both)results in higher drug exposure than the dose used to establish the susceptible breakpoint for AST guidelines.SDD is assigned when doses well above those used to calculate the susceptible breakpoint are approved and used clinically,and where sufficient data to justify the designation exist and have been reviewed.

A Newly Defined Interpretive Category Termed "Susceptible-Dose Dependent" (SDD)implies Susceptibility