The inhibition zone size and minimal inhibitory concentration (MIC)interpretive criteria published by the Clinical and Laboratory Standards Institute (CLSI)are established by careful analysis of all of the following EXCEPT:
A) Microbiologic data
B) Pharmacokinetic data
C) Results of clinical studies during the phase before Food and Drug Administration (FDA) approval
D) Pharmacodynamic data

Question

Quizplus · Accepted Answer

The inhibition zone size and MIC interpretive criteria published by the CLSI are established by careful analysis of three kinds of data: microbiologic data (e.g.,a comparison of MICs versus zone sizes on a large number of bacterial strains,including those with known resistance mechanisms),pharmacokinetic data (e.g.,serum,cerebrospinal fluid [CSF],urine,and other secretion and tissue levels of an antimicrobial agent),and results of clinical studies obtained during the phase before FDA approval and marketing of an antimicrobial agent.

The Inhibition Zone Size and Minimal Inhibitory Concentration (MIC)interpretive Criteria