Resistance to aminoglycosides is mediated by:
A) Efflux
B) Changes in the target site
C) Impermeability or by enzymatic modification of amino and hydroxy moieties appended to the cyclitol rings
D) All of the above

Question

Quizplus · Accepted Answer

Resistance to aminoglycosides is mediated by efflux,changes in target site,impermeability,or enzymatic modification of the amino and hydroxy moieties appended to the cyclitol rings.The most clinically relevant is enzymatic modification,which prevents recognition of the 16S binding sites and subsequent inhibition of mRNA translation.

Resistance to Aminoglycosides Is Mediated By