During strenuous exercise,the muscles' use of oxygen and nutrients can outstrip the blood's ability to supply them.

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During strenuous exercise, the muscles require more oxygen and nutrients to keep up with the demand for energy, and this demand can exceed the capacity of the cardiovascular system to deliver oxygen and nutrients to working muscles. As a result, the muscles shift to anaerobic metabolism, which generates energy without oxygen but produces lactic acid as a byproduct, leading to muscle fatigue and discomfort.

During Strenuous Exercise,the Muscles' Use of Oxygen and Nutrients Can