Select the pathway that would lead to the activation of B cells in the humoral immune response.
A)B cell internalizes antigen → helper T cell binds to class II MHC molecule-antigen complex → B cell proliferates and differentiates → activated helper T cell binds to B cell and releases cytokines
B)self-tolerance of immune cells → B cells contact antigen → cytokines released
C)complement is secreted → B cell contacts antigen → helper T cell activated → cytokines released
D)B cell internalizes antigen → class II MHC molecule-antigen complex displayed→ activated helper T cell binds to B cell and releases cytokines → B cell proliferates and differentiates
E)natural killer cells → class II MHC molecule-antigen complex displayed → cytokines released → cell lysis

Question

Quizplus · Accepted Answer

The pathway that leads to the activation of B cells in the humoral immune response involves the internalization of antigen by the B cell, which is then displayed on the cell surface in complex with class II MHC molecules. An activated helper T cell recognizes this complex, binds to the B cell, and releases cytokines, which triggers the proliferation and differentiation of the B cell into antibody-secreting plasma cells. Choice D accurately describes this pathway by including all the necessary steps.

Select the Pathway That Would Lead to the Activation of B